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ketoconazole, ritonavir) increase tadalafil tablets exposure (, , ) requiring dose adjustment:•Tadalafil tablets for use as needed: no more than 10 mg every 72 hours•Tadalafil tablets for once daily use: dose not to exceed 2.5 mg•CYP3A4 inducers (e.g. rifampin) decrease tadalafil tablets exposure ().USE IN SPECIFIC POPULATIONSHepatic Impairment (2.6, , ):•Mild or Moderate: Dosage adjustment may be needed.•Severe: Use is not recommended.Renal Impairment (2.6, , ):•Patients with creatinine clearance 30 to 50 mL/min: Dosage adjustment may be needed.•Patients with creatinine clearance less than 30 mL/min or on hemodialysis: For use as needed: Dose should not exceed 5 mg every 72 hours. Once daily use is not recommended.See 17 for PATIENT COUNSELING INFORMATION.Revised: 6/2023 Tadalafil tablets are a phosphodiesterase 5 (PDE5) inhibitor indicated for the treatment of: (1) the signs and symptoms of benign prostatic hyperplasia (BPH) () ED and the signs and symptoms of BPH (ED/BPH) () If tadalafil tablets are used with finasteride to initiate BPH treatment, such use is recommended for up to 26 weeks ().
| Storage Aspect | Condition | Notes |
|---|---|---|
| Temperature | Below 30°C (86°F) | Keep away from heat and moisture |
| Light Exposure | Store in a dark place | Protect from light |
| Keep Out of Reach | Children and pets | Safety precaution |
| Packaging | Original container | Keep sealed and intact |
| Expiry Date | Refer to packaging | Do not use past expiration date |
ED: Starting dose: 10 mg as needed prior to sexual activity.
- Tadalafil 5mg is primarily used to treat erectile dysfunction.
- It works by relaxing blood vessels in the penis.
- Typically taken once daily for ongoing management.
Not to be taken more than once per day ().
- Tadalafil 5mg can be part of a comprehensive ED treatment plan.
- Lifestyle changes like exercise and quitting smoking may enhance results.
- Regular medical check-ups are recommended during use.
ED: 2.5 mg taken once daily, without regard to timing of sexual activity. May increase to 5 mg based upon efficacy and tolerability (). BPH: 5 mg, taken at approximately the same time every day () ED and BPH: 5 mg, taken at approximately the same time every day (, ) Tadalafil tablets may be taken without regard to food (). Administration of tadalafil tablets to patients using any form of organic nitrate is contraindicated.
| Condition | Caution/Advice |
|---|---|
| Nitrate Use | Do not combine; risk of severe hypotension |
| Cardiovascular Disease | Consult doctor before use |
| Liver Impairment | Dose adjustment may be necessary |
| Recent Stroke or Heart Attack | Seek medical advice before starting therapy |
| Hypotension | Avoid use; blood pressure should be stable |
Tadalafil tablets were shown to potentiate the hypotensive effect of nitrates (). History of known serious hypersensitivity reaction to tadalafil tablets or ADCIRCA® ().
- Some people may experience nasal congestion or dizziness.
- Use caution when combining with other erectile dysfunction drugs.
- Always keep medication out of reach of children.
Administration with guanylate cyclase (GC) stimulators, such as riociguat (). Patients should not use tadalafil tablets if sex is inadvisable due to cardiovascular status (5.1).
Understanding Erectile Dysfunction (ED)
Caution is advised when tadalafil tablets are used as a treatment for ED in men taking alpha-blockers. (, 5.6, , )•Patients should seek emergency treatment if an erection lasts >4 hours. Use tadalafil tablets with caution in patients predisposed to priapism ().•Patients should stop tadalafil tablets and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of non-arteritic anterior ischemic optic neuropathy (NAION). Tadalafil tablets should be used with caution, and only when the anticipated benefits outweigh the risks, in patients with a history of NAION. Patients with a “crowded” optic disc may also be at an increased risk of NAION (, ).•Patients should stop tadalafil tablets and seek prompt medical attention in the event of sudden decrease or loss of hearing ().•Prior to initiating treatment with tadalafil tablets for BPH, consideration should be given to other urological conditions that may cause similar symptoms ().ADVERSE REACTIONSDRUG INTERACTIONS•Tadalafil tablets can potentiate the hypotensive effects of nitrates, alpha-blockers, antihypertensives or alcohol ().•CYP3A4 inhibitors (e.g. Use of tadalafil tablets with alpha-blockers, antihypertensives or substantial amounts of alcohol (≥5 units) may lead to hypotension (5.6, ). Tadalafil tablets are not recommended in combination with alpha-blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Cialis Generic | 20mg | 270 + 10 Pills | 335.21€ 319.25€ | |
| Cialis Generic | 60mg | 120 + 8 Pills | 240.18€ 228.74€ | |
| Cialis Generic | 60mg | 90 + 6 Pills | 196.67€ 187.30€ | |
| Cialis Generic | 20mg | 10 Pills | 31.49€ 29.99€ | |
| Cialis Generic | 10mg | 180 + 8 Pills | 236.88€ 225.60€ | |
| Tadalista Super Active | 20mg | 10 Pills | 55.64€ 52.99€ | |
| Cialis Generic | 40mg | 10 Pills | 37.79€ 35.99€ | |
| Cialis Generic | 2.5mg | 90 + 6 Pills | 112.43€ 107.08€ | |
| Cialis Generic | 20mg | 120 + 8 Pills | 188.15€ 179.19€ | |
| Tadalista Super Active | 20mg | 20 + 4 Pills | 92.35€ 87.95€ |
Patients should seek emergency treatment if an erection lasts >4 hours.
8.6 Hepatic Impairment
Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669. Do not share this medication with others. If you are taking this medication on a regular schedule and you miss a dose, take it as soon as you remember.
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If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up. Store at room temperature away from light and moisture. Keep all medications away from children and pets.
What are the serious side effects of tadalafil?
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. This information does not assure that this product is safe, effective, or appropriate for you. Use tadalafil tablets with caution in patients predisposed to priapism (). Patients should stop tadalafil tablets and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of non-arteritic anterior ischemic optic neuropathy (NAION). Patients with a “crowded” optic disc may also be at an increased risk of NAION (, ).
5.1 Cardiovascular
This information is not individual medical advice and does not substitute for the advice of your health care professional. Always ask your health care professional for complete information about this product and your specific health needs. Selected from NATIONAL DRUG DATA FILE (NDDF) data included with permission and copyrighted by First Databank, Inc., 2019. This copyrighted material has been downloaded from a licensed data provider. The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional.
Other Interactions
You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment. Early birth safer for mother and baby in high blood pressure pregnancies 21 May 2026Planned early birth for pregnant women with high blood pressure cuts maternal complications by nearly half and reduces the risk of stillbirth, without increasing the likelihood of caesarean section, according to a new Cochrane review. Planned early birth for pregnant women with high blood pressure cuts maternal complications by nearly half and reduces the risk of stillbirth, without increasing the likelihood of caesarean section, according to a new Cochrane review. From evidence to impact: how Cochrane Thailand is turning research into practice 18 May 2026Discover the role Cochrane Thailand has played in closing the gap between evidence and outcomes. Designated as a WHO Collaborating Centre for Research Synthesis in Reproductive Health, the group has not only generated Cochrane reviews but has also translated those findings into national policy and clinical guidelines.
Pulmonary arterial hypertension
Discover the role Cochrane Thailand has played in closing the gap between evidence and outcomes. Screening modestly reduces prostate cancer deaths 11 May 2026Blood tests to detect potential signs of prostate cancer likely reduce the risk of dying from prostate cancer, an updated Cochrane review finds. This is a shift from the previous version of the review. Blood tests to detect potential signs of prostate cancer likely reduce the tadalafil in women risk of dying from prostate cancer, an updated Cochrane review finds. If you are a consumer or patient please visit this version. Patients should stop tadalafil tablets and seek prompt medical attention in the event of sudden decrease or loss of hearing (). Prior to initiating treatment with tadalafil tablets for BPH, consideration should be given to other urological conditions that may cause similar symptoms ().
Are erectile dysfunction medicines safe?
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use TADALAFIL TABLETS safely and effectively. See full prescribing information for TADALAFIL TABLETS.TADALAFIL tablets for oral use.Initial U.S. Approval: 2003RECENT MAJOR CHANGESWarnings and Precautions () 05/2017INDICATIONS AND USAGETadalafil tablets are a phosphodiesterase 5 (PDE5) inhibitor indicated for the treatment of: (1)•erectile dysfunction (ED) ()•the signs and symptoms of benign prostatic hyperplasia (BPH) ()•ED and the signs and symptoms of BPH (ED/BPH) ()If tadalafil tablets are used with finasteride to initiate BPH treatment, such use is recommended for up to 26 weeks (). (1)DOSAGE AND ADMINISTRATION•Tadalafil tablets for use as needed:•ED: Starting dose: 10 mg as needed prior to sexual activity. Increase to 20 mg or decrease to 5 mg based upon efficacy/tolerability.
Consent for publication
Improves erectile function compared to placebo up to 36 hours post dose. Not to be taken more than once per day ().•Tadalafil tablets for once daily use:•ED: 2.5 mg taken once daily, without regard to timing of sexual activity. May increase to 5 mg based upon efficacy and tolerability ().•BPH: 5 mg, taken at approximately the same time every day ()•ED and BPH: 5 mg, taken at approximately the same time every day (, )•Tadalafil tablets may be taken without regard to food ().DOSAGE FORMS AND STRENGTHSTablets: 2.5 mg, 5 mg, 10 mg, 20 mg (). (3)CONTRAINDICATIONS•Administration of tadalafil tablets to patients using any form of organic nitrate is contraindicated. Tadalafil tablets were shown to potentiate the hypotensive effect of nitrates ().•History of known serious hypersensitivity reaction to tadalafil tablets or ADCIRCA® ().•Administration with guanylate cyclase (GC) stimulators, such as riociguat ().WARNINGS AND PRECAUTIONS•Patients should not use tadalafil tablets if sex is inadvisable due to cardiovascular status (5.1).•Use of tadalafil tablets with alpha-blockers, antihypertensives or substantial amounts of alcohol (≥5 units) may lead to hypotension (5.6, ).•Tadalafil tablets are not recommended in combination with alpha-blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering. Tadalafil tablets can potentiate the hypotensive effects of nitrates, alpha-blockers, antihypertensives or alcohol (). ketoconazole, ritonavir) increase tadalafil tablets exposure (, , ) requiring dose adjustment: Tadalafil tablets for use as needed: no more than 10 mg every 72 hours Tadalafil tablets for once daily use: dose not to exceed 2.5 mg Mild or Moderate: Dosage adjustment may be needed.