Legal Status of Sildenafil Around the World
It’s possible to develop long-term side effects from sildenafil treatment. In clinical trials,* long-term side effects, such as vision loss and hearing loss,† occurred at any time during treatment. However, the exact reason why these side effects occurred is not fully known. If you have any sudden changes in your vision or hearing, talk with your doctor right away.
Mechanism of action
Here are some frequently asked questions about the drug’s side effects and their answers. No, there aren’t any reviews from people who’ve taken 50-milligram (mg) or 100-mg sildenafil tablets. However, you may experience mild or severe side effects from sildenafil with any prescribed dose. In clinical trials,* a similar number of people reported certain side effects with both 50-mg and 100-mg doses. These side effects included mild to moderate headaches, flushing, and back pain.
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
However, people taking the 100-mg dose had an increased risk of upset stomach, vision changes, and runny nose. If you have questions about the side effects of your prescribed sildenafil dose, talk with your doctor or pharmacist. * To learn more about the clinical trials of sildenafil, refer to the drug’s prescribing information for erectile dysfunction and pulmonary arterial hypertension (PAH). No, sildenafil isn’t known to cause different side effects in females. * Sildenafil is approved to treat PAH in most adults, including females.
Azole Antifungals
If you’re female and concerned about side effects with sildenafil, talk with your doctor. Note: If you’re male, priapism may occur during sildenafil treatment. With priapism, you experience a continued (4 hours or longer) erection that’s often painful. For more information about this side effect, see the “Sildenafil: Side effect specifics” section below. Use of the term “female” and “male” in this article refers to sex assigned at birth. Also talk with them if you’re concerned about long-term side effects with sildenafil treatment. * To learn more about the clinical trials of sildenafil, refer to the drug’s prescribing information for erectile dysfunction and pulmonary arterial hypertension. † For more details about these side effects, including their symptoms, see the “Sildenafil: Serious side effects” section above. Learn more about some of the side effects that sildenafil may cause. To find out how often side effects occurred in clinical trials, see the drug’s prescribing information for erectile dysfunction (ED) and sildenafil 10mg pulmonary arterial hypertension (PAH). However, this side effect was rare in clinical trials.
| Country | Status | Remarks |
|---|---|---|
| USA | Prescription-only | Approved for ED |
| UK | Prescription-only | Licensed medication |
| India | OTC (some brands) | Available with or without prescription |
| Australia | Prescription required | Controlled substance |
* Sildenafil is a vasodilator, meaning it widens the blood vessels and makes it easier for blood to flow. When this happens, your blood pressure may drop. This is because your heart doesn’t have to work as hard to move blood around your body.
- Sildenafil may improve confidence and sexual satisfaction in men with ED.
- The medication is also being researched for pulmonary hypertension treatment.
- Common side effects include dizziness, upset stomach, and vision changes.
- Rare side effects can include priapism, a painful prolonged erection.
- Alcohol can interfere with sildenafil's effectiveness and increase side effects.
- Patients should disclose any heart conditions before using sildenafil.
- Sildenafil may interact with other medications such as alpha-blockers.
- It is not suitable for individuals with severe liver or kidney problems.
- Taking large doses does not necessarily improve efficacy and increases risk.
- Always follow the prescribed dosage and discontinue if adverse effects occur.
Signs and symptoms of low blood pressure include tiredness, lightheadedness, or blurry vision.
| Age Range | Suitability | Notes |
|---|---|---|
| 18-50 years | Usually suitable | Under doctor supervision |
| 51-70 years | Caution advised | Dose adjustment may be needed |
| Over 70 years | Use with caution | Potential drug interactions |
They may also include nausea, dizziness, fainting, and confusion. Low blood pressure can be mild or severe depending on how much your blood pressure drops. You may have an increased risk of severe low blood pressure if you: already take drugs to lower your blood pressure have a blood pressure less than 90/50 before taking sildenafil If you take blood pressure drugs during sildenafil treatment, your doctor will recommend monitoring your blood pressure regularly.
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If you notice any signs or symptoms of low blood pressure while taking sildenafil, talk with your doctor. They’ll review your symptoms and other medications to make sure it’s safe for you to keep taking the drug. * To learn more about the clinical trials of sildenafil, refer to the drug’s prescribing information for ED and PAH. Headache is a possible side effect while taking sildenafil. Headaches were common and typically mild in clinical trials of the drug.* If you start to experience headaches often or if they affect your daily life, talk with your doctor. They may recommend lifestyle changes, such as more rest to help ease your headache. Your doctor may also recommend pain medications to help treat your headache. These may include ibuprofen (Advil, Motrin) or acetaminophen (Tylenol).
| Medication Type | Interaction Effect | Notes |
|---|---|---|
| Nitrates | Severe hypotension | Contraindicated |
| Alpha-blockers | Blood pressure drop | Adjust dosage or use with caution |
| CYP3A4 inhibitors | Increased sildenafil levels | Monitor for side effects |
| Antibiotics (e.g., erythromycin) | Potential increased plasma concentration | Caution required |
Severe cardiovascular problems may occur during sildenafil treatment. This side effect was reported* in people taking sildenafil for ED after the drug was approved. Cardiovascular problems, such as heart attack, stroke, irregular heartbeat, lung bleeding, and brain bleeding were rarely reported. Many of these reported side effects occurred during or shortly after sexual activity. Most of the people who experienced cardiovascular problems during sildenafil treatment already had other heart-related conditions. So it’s unknown if sildenafil was the direct cause of these side effects.
Pregnancy & Lactation
The list below may not include all possible serious side effects of the drug. If you develop serious side effects while taking sildenafil, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number. Serious side effects that have been reported and their symptoms include: Symptoms can include:tinnitus (ringing in your ear)dizzinessdecrease in hearing Symptoms can include:trouble seeing in either eyeblurry visionseeing eye floaters * To learn more about this side effect, see the “Sildenafil: Side effect specifics” section below. Sildenafil is not approved by the Food and Drug Administration (FDA) for use in children.
Distribution of Dispensed Dosage Forms (2023)
In clinical trials, children who were given sildenafil long term to treat pulmonary arterial hypertension had an increased risk of fatality. However, your child’s doctor may recommend taking sildenafil off-label in some cases. (With off-label use, a doctor prescribes an FDA-approved drug for a purpose other than what it’s approved for.) Talk with your child’s doctor to determine if sildenafil is right for your child. They can help compare the risks and benefits of the drug. Sildenafil oral tablets come in different strengths: 20 milligrams (mg), 25 mg, 50 mg, and 100 mg.
Serious Side Effects
The dosage you’re prescribed will depend on what condition you’re taking sildenafil for. It also depends on how the dosage is working for you. You can experience mild or severe side effects from sildenafil with sildenafil 45 mg chewable tablets any dosage. However, you may have an increased risk of side effects with higher dosages. If you start to experience side effects that become bothersome or severe while taking sildenafil, talk with your doctor. They may be due to other factors, such as preexisting heart disease, sexual activity, or a combination of these factors. Before you start sildenafil treatment, be sure to tell your doctor if you have any heart conditions.
What happens if I miss a dose?
Uncensored & Professional, with our doctors and members of SuamiSihat Community. SS Clinic is the first and one of its kind to advocate on high quality treatment, medication as well as supplements for men's health at an affordable cost. Join our email list and get exclusive access to new products, treatment deals & promotions Sildenafil (Revatio, Viagra) is a generic prescription medication used to treat erectile dysfunction and pulmonary arterial hypertension in adults. Sildenafil, which is also called sildenafil citrate, comes as an oral tablet. The drug also comes as an oral liquid suspension and IV infusion.
Dosage Modifications
However, this article does not cover these forms. It only covers the side effects of sildenafil oral tablets. If you’d like to learn more about these forms, talk with your doctor. As with other drugs, sildenafil can cause side effects (adverse effects). It’s typically taken as a long-term treatment.
Related Drugs
Read on to learn about potential common, mild, and serious side effects. For a general overview of sildenafil, including details about its uses, refer to this article. Your doctor can also tell you more about sildenafil. Sildenafil can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days to weeks. Depending on your heart health, sildenafil may not be safe for you to take.
- Sildenafil can sometimes cause flushing and nasal congestion.
- It is not a cure for erectile dysfunction, only a treatment option.
- Psychological factors can also affect erectile performance alongside medication.
- Sildenafil may sometimes interact with foods that contain high fat content.
- Regular exercise and stress management can complement treatment with sildenafil.
- The medication should be stored safely out of children's reach.
- Reporting side effects to a healthcare provider is important for safety.
- Sildenafil is typically started at a low dose, gradually increased if needed.
- It is important to follow the prescribed timing for medication intake.
- Discontinuing sildenafil should be discussed with a healthcare professional.
Your doctor can review the risks and benefits of taking sildenafil to determine the right treatment plan for you. If you’re interested in having sex while taking sildenafil for ED or PAH, talk with your doctor before starting treatment.
Are There Any Downsides to Combination Therapy?
However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. These are just a few of the more common side effects reported by people who took sildenafil in clinical trials:* * To learn more about the clinical trials of sildenafil, refer to the drug’s prescribing information for erectile dysfunction and pulmonary arterial hypertension. † For more information about this side effect, see “Sildenafil: Side effect specifics” below. Optum Perks is owned by RVO Health. By clicking on this link, we may receive a commission.
Dangerous Interactions
Mild side effects can occur with sildenafil use. This list doesn’t include all possible mild side effects of the drug. For more information, you can refer to sildenafil’s prescribing information for erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). Mild side effects that have been reported with sildenafil include: These side effects may be temporary, lasting a few days to weeks. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication.
Mechanism of Action
If you develop a side effect while taking sildenafil and want to tell the FDA about it, visit MedWatch. * For more information about this side effect, see “Sildenafil: Side effect specifics” below. † An allergic reaction is possible after taking sildenafil. However, this side effect was rarely reported in clinical trials of sildenafil for ED and PAH. To learn more, see the “Sildenafil: Side effect specifics” section below. It’s important to talk with your doctor about your heart health before having sex. Engaging in sexual activity when you have heart problems may increase your risk of severe cardiovascular problems, including heart attack.
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